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Little-molecule inhibitors from the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic sort of cell Demise called pyroptosis in mouse and human monocytes and macrophages1,2. In mouse myeloid cells, Dpp8/nine inhibition activates the inflammasome sensor Nlrp1b, which in turn activates pro-caspase-1 to mediate cell death3, although the mechani